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Hormones and their presence in environmental
Sučková, Tereza ; Dvořáková, Petra (referee) ; Vávrová, Milada (advisor)
This thesis deals with the issue of hormones in the environment and analytical methods for the determination of hormonal substances in water and soil ecosystems. The thesis includes an overview of important hormone groups (divided into categories according to their chemical structure) and basic information about properties of chosen hormones, their sources and impacts on the environment. The next focuses upon methods of determination of hormones in soil and water ecosystems. Finally, a standard operational manual for analysis of estrogens in surface water has been created and is provided herein.
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Ecotoxicity of substances with hormonal effect
Cvikýřová, Zuzana ; Vávrová, Milada (referee) ; Zlámalová Gargošová, Helena (advisor)
This bachelor thesis deals with the fate and ecotoxicity of chosen substances with hormonal effect in the environment. This group of compounds covers steroid hormones, which are produced for these effects, but also a lot of xenobiotics, showing similar activity. The substances disrupt the endocrine system by various mechanisms. They can cause feminization, masculinization, disruption of reproduction, etc. In terms of chemical structure they belong to the group of phthalates, polychlorinated biphenyls, pesticides, heavy metals and others. The impact of these substances, especially on the aquatic ecosystem, which becomes their reservoir in most cases, was assessed.
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Determination of hormones in wastewater
Zouharová, Kamila ; Tulková, Tereza (referee) ; Vávrová, Milada (advisor)
The presented theoretical and practical study was focused on a single unit of drugs – hormones. In the present study were characterized in detail hormones as drugs or medical ressource and their mode of effect on the human body. Another important part of this study was focused on the evaluate of the incidence of estrogens in the environment and their possible impact on the aquatic ecosystem, mainly for waste water. The last part of study was processed analytical problems of determination of hormones. There were introduced pre-analytical and analytical methods – methods of isolation of hormones from the waste water and methods of thein final determination, which were based mainly on the separation processes.
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Assessment of the drinking water treatment plant effectiveness via ecotoxicological tests and screening analyses
Nývltová, Barbora ; Mravcová, Ludmila (referee) ; Zlámalová Gargošová, Helena (advisor)
The quality of raw water is deteriorating with the continuous increase in environmental pollution. Raw water is being modified to drinking water by technological processes, and it is therefore necessary to put increased demands on the efficiency of these technological processes and their possible innovation. Due to the fact that raw water is contaminated with different types of pollutants, it is necessary to continuously control the drinking water supplied to the public distribution network in order to ensure its quality. Drinking water treatment is still unable to treat the raw water perfectly, its pollution is only reduced to acceptable standards. For this reason, it is indispensable that the quality of drinking water is being checked regularly and at the same time the efficiency of individual technological processes of drinking water treatment is assessed. This includes screening analysis or eventually ecotoxicological tests. The thesis focuses on the efficiency of technological processes of drinking water treatment. Within the experimental part, samples of raw water and samples of water after each separation stage have been collected at the drinking water treatment plant in the Czech Republic. These samples have been subjected to ecotoxicological tests and screening analysis. Based on the ecotoxicological tests carried out on Thamnocephalus platyurus, Lemna minor and Vibrio fischeri, we can assume the emergence of harmful chlorinated by-products, resulting to nearly 100% mortality in T. platyurus. The results of the screening analysis carried out indicate, after the extraction of specimens by the SPE method using HPLC/MS, that the most effective method for the removal of hormonal substances is ozonization.
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Interactions of hormones and drugs with soil organic matter
Krajňáková, Soňa ; Enev, Vojtěch (referee) ; Klučáková, Martina (advisor)
This thesis is focused on the problem of interaction of hormones and drugs with a soil organic matter. The most commonly occurring drugs are described, as well as their features, behaviour and possible factors influencing this behaviour. These substances are frequently transported to the soil through a sewage treatment plant, as the cleaning process of wastewater is not effective enough to ensure complete removal of these substances. Once in the soil, the life of organisms in this environment can be negatively influenced. The soil used in experiments was not contaminated with any of these substances as it was used as a matrix for sorption and desorption. Two experiments were conducted using Ibuprofen, where its sorption and desorption on the soil was observed. The intention was to ensure detection of changes which occurred in the concentration of Ibuprofen after concluding these processes. Liquid chromatography method with mass spectrometric detection was used for a final analysis.
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The influence of thyroid hormones and adrenal glands on mental function
Augustinová, Jana ; Šivicová, Gabriela (advisor) ; Špinka, Marek (referee)
This thesis focuses on effects of thyroid and adrenal hormones on mental functions, especially on cognitive functions and emotions. In the case of adrenal hormones it will also focus on stress and burnout syndrome, which are not considered as mental functions, but are connected to both psyche and the above mentioned hormones. The text is divided into two parts. The first, theoretical part deals with the anatomy and histology of these two organs, hormones that they produce and their influence on overall physical condition and pathology. The main section of this theoretical part deals with the description of influence of thyroid hormones and adrenal glands on the above mentioned mental functions. This work is based on both earlier and contemporary research, but predominantly on foreign research. In the second, empirical part, a proposal for longitudinal study of cortisol and thyroxine levels during depression treatment is presented. Klíčová slova: Hormones, thyroid glang, adrenal gland, mental functions, cognitive functions, emotions, stress, cortisol, thyroxine
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Anxiety disorders from a biological and psychological perspective
Záplatová, Klára ; Šivicová, Gabriela (advisor) ; Hrachovinová, Tamara (referee)
Barchelor thesis focuses on anxiety disorders from a biological and psychological perspective. This thesis aims to provide anxiety disorders in their entireness. For this reason, thesis focuses on psychological and physical symptoms of anxiety. Topic contains unconscious symptoms manifesting inside of a man. Thesis is divided into two main parts. First one consists of literature review, the second one consists of experiment design. Experiment design deals with physiological symptoms of social phobia. It is focused on specific brain areas and cortisol level in anxiety feeling as well as to feeling of a man during the experiment. Powered by TCPDF (www.tcpdf.org)
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Circadian system and reproduction
Hrubá, Anežka ; Lužná, Vendula (advisor) ; Ladislavová, Lucie (referee)
Due to the alternation of day and night, mammals have developed internal circadian clocks, helping to synchronize physiological processes with the external environment. The circadian system is hierarchically organized, with central clocks located within suprachiasmatic nuclei of the hypothalamus (SCN). The main signal for setting the clocks to the external time is light, which enters the SCN through retina. The SCN communicate with peripheral oscillators in other organs, including reproductive ones, via hormonal signals, thereby synchronizing a variety of physiological processes. At the molecular level, clocks are controlled by clock genes. Cicradian system has a significant impact on reproduction. It is manifested by rythmical expression of clock genes and production of hormones in reproductive organs, as well as a success in reproduction if the clock's function is proper, and problems with reproduction if it is not. From a gender perspective, a several differences between women and men has been found throughout the SCN. Likewise, there are differences in chronotypes between both sexes over the course of their lives. Biological rhythms also include circannual rhythms, contributing to the timing of reproduction at the proper season of the year. Animals mate at different time depending on the length...
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Regulation of insect pheromone biosynthesis
Halmová, Martina ; Pichová, Iva (advisor) ; Valterová, Irena (referee)
Pheromones are compounds emitted by insects and vertebrates that specifically modulate the behaviour of the same species. Based on the role, pheromones are classified into different types such as releaser pheromones, primer pheromones, sex pheromones, aggregation pheromones, alarm pheromones and trail pheromones. Insect pheromones are volatile substances consisting mostly of alcohols, aldehydes, ketones, aromatic compounds and isoprenoids. Pheromone biosynthesis comprises fatty acid and isoprenoid metabolic pathways. Pheromone biosynthesis must be precisely regulated since the pheromone blend consists of a mixture of compounds with defined ratios and chemical structures. The main aim of this thesis is to summarize the published information about insect pheromone biosynthesis and regulation with a focus on pheromones involved in sexual communication. Attention will also be paid to the biotechnological potential of pheromones in targeted pest management with the utilisation of enzymes present in the biosynthesis of pheromones.
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